Dan Park

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue, L-452
Livermore, CA 94550
email: park36@llnl.gov
phone: 925 423 7508


B.S., Chemistry, Colorado School of Mines - 2008

Ph.D., Biochemistry, University of Wisconsin at Madison - 2013


Research interests

Biochemistry, Genomics, Synthetic Biology, & Environmental Microbiology: Development of biology-based approaches for critical metal recovery. Characterizing the molecular mechanisms and gene expression programs that support resistance of bacteria to environmental stresses or facilitate unique metabolic capabilities. Development of biocontainment mechanisms for environmental deployment of genetically modified microorganisms.


J.L. Chlebek, S.P. Leonard, C.S. Kang-Yun, M.C. Yung, D.P. Ricci, Y. Jiao, D.M. Park. Prolonging Genetic Circuit Stability through Adaptive Evolution of Overlapping Genes.
Nucleic Acids Research (2023).

J. A. Mattocks, J.J. Jung, C.-Y. Lin, Z. Dong, N.H. Yennawar, E.R. Featherston, C.S. Kang-Yun, T.A. Hamilton, D.M. Park*, A.K. Boal*, J.A Cotruvo.* Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer. Nature (2023). vol 618, 87–93. 

T.M. Halvorsen, D.P. Ricci, D.M. Park, Y. Jiao, and M.C. Yung (2022). Comparison of Kill Switch Toxins in Plant-Beneficial Pseudomonas fluorescens Reveals Drivers of Lethality, Stability, and Escape. ACS Synthetic Biology, vol 11 (11), 3785–3796. 

Guzman, M., Reed, D., Yoshiko, F., Jiao, Y., Park, D.M.*(2022) Complete Genome Sequence of Acidithiobacillus ferriphilus GT2, Isolated from Gold Mill Tailings. Microbiology Resource Announcements. Vol 11, No 2.

Dong, Z., Mattocks, J.A., Deblonde, G., Dehong, H., Jiao, Y., Cotruvo, J.A.*, and Park, D.M.* (2021) Bridging Hydrometallurgy and Biochemistry: A Protein-based Process for Recovery and Separation of Rare Earth Elements, ACS Central Science. 7, 11, 1798–1808.

Fujita, Y., D. Park, M. Lencka, A. Anderko, D. Reed, V. Thompson, G. Das, A. Eslamimanesh, and Y. Jiao. Beneficiation of REE: Prospects for biotechnology deployment. Rare Earth Elements: Sustainable Processing, Purification, and Recovery, American Geophysical Union (AGU)-Wiley Geophysical Monograph Series. Posted on Earth and Space Science Open Archive.

Dong, Z., Deblonde, G., Middleton, A., Hu, D., Dohnalkova, A., Kovarik, L., Qafoku, O., Shutthanandan, V., Jin, H., Hsu-Kim, H., Theaker, N., Jiao, Y., and Park, DM*. (2021) Microbe-Encapsulated Silica Gel Biosorbents for Selective Extraction of Scandium from Coal Byproducts, Environ. Sci. Technol. 55, 9, 6320–6328.

Dubbin, K., Dong, Z., Park, D.M., Alvarado, J., Su, J., Wasson, E., Robertson, C., Jackson, J., Bose, A., Moya, M. L., Jiao, Y., and Hynes, W. F. (2021) Projection Microstereolithographic Microbial Bioprinting for Engineered Biofilms, Nano Letters 21, 1352-1359.

Park, DM*, Middleton, A., Smith, R., Deblonde, G., Laudal, D., Theaker, N., Hsu-Kim, H., and Jiao, YA. A biosorption-based approach for selective extraction of rare earth elements from coal byproducts. Separation and Purification Technology, 2020. 241: p. 116726.

Deblonde, G. J. P., Mattocks, J. A., Park, DM, Reed, D.W., Cotruvo, J.A., and Jiao, Y. (2020) Selective and Efficient Biomacromolecular Extraction of Rare-Earth Elements using Lanmodulin, ACS Inorg. Chem. 59, 17, 11855–11867.

Alipanah M, Park, DM, Middleton, A, Dong Z, Hsu-Kim, H, Jiao, Y, Jin H (2020). Techno-economic and Life Cycle Assessments for Sustainable Rare Earth Recovery from Coal Byproducts using Biosorption.  ACS Sustainable Chemistry and Engineering. 8, 49, 17914–17922.

E. Chang, A.W. Brewer , D.M. Park, Y. Jiao, and L.N. Lammers (2020). Selective Biosorption of Valuable Rare Earth Elements Among Co-occurring Lanthanides.  Environmental Engineering Science. 38, 3.

Middleton, A, Park, DM, Jiao, Y, Hsu-Kim, H. (2020). Major element composition controls rare earth element solubility during leaching of coal fly ash and coal by-products. Intl. J. Coal Geology. 227, 103532. 

Chang, E., Brewer, A. W., Park, D.M., Jiao, Y., and Lammers, L. N. (2020) Surface complexation model of rare earth element adsorption onto bacterial surfaces with lanthanide binding tags, Applied Geochemistry 112, 104478.

Park DM*, Taffet MJ. (2019) A combinatorial sensor design in Caulobacter crescentus for selective environmental uranium detection. ACS Synthetic Biology. 8(4): 807-817.

Park DM, Overton KW, Jiao Y (2019) The UzcRS two-component system in Caulobacter crescentus integrates regulatory input from diverse auxiliary regulators.  Molecular Microbiology. 111(3):678-699.

Brewer, A., Dohnalkova, A. C., Shutthanandan, V., Kovarik, L., Chang, E., Sawvel, A. M., Mason, H. E., Reed, D. W., Ye, C., Hynes, W. F., Lammers, L. N., Park, D. M.*., and Jiao, Y*. Microbe Encapsulation for Selective Rare-Earth Recovery from Electronic Waste Leachates (2019) Environ Sci Technol. 53, 23, 13888–13897

Brewer, A., Chang, E., Park, D. M., Kou, T., Li, Y., Lammers, L. N., and Jiao, Y. (2019) Recovery of Rare Earth Elements from Geothermal Fluids through Bacterial Cell Surface Adsorption, Environ. Sci. Technol. 53, 7714-7723.

Park DM, Brewer A, Reed DW, Hageman PL, Lammers, LN, Jiao Y. (2017) Recovery of Rare Earth Elements from Low-Grade Feedstock Leachates using Engineered BacteriaEnviron. Sci. Technol., 5113471–13480.

Jin H., Park DM,  Gupta M, Brewer A, Ho L, Singer S,  Bourcier W; Woods S, Reed, D, Lammers L, Sutherland J, Jiao Y (2017).  Techno-Economic Assessment for Integrating Biosorption into Rare Earth Recovery Process.  ACS Sustainable Chem. Eng.,  5, 10148–10155.

Park DM, Overton KW, Liou MJ, Jiao Y (2017) Identification of a U/Zn/Cu responsive global regulatory two-component system in Caulobacter crescentus. Molecular Microbiology 104(1):46-64.

Park DM, Reed DW, Yung MC, Eslamimanesh A, Lencka  MM, Anderko A, Fujita Y, Riman RE, Navrotsky A, Jiao Y. (2016) Bioadsorption of Rare Earth Elements through Cell Surface Display of Lanthanide Binding Tags. Environ Sci Technol. 10.1021/acs.est.5b06129.

Beauchene NA, Myers KS, Chung D, Park DM, Weisnicht AM, Keleş S, Kiley PJ. 2015. Impact of anaerobiosis on expression of the iron-responsive Fur and RyhB regulons. mBio 6(6):e01947-15. doi:10.1128/mBio.01947-15.

Yung, M. C., Park, D. M., Overton, K. W., Blow, M. J., Hoover, C. A., Smit, J., Murray, S. R., Ricci, D. P., Christen, B., Bowman, G. R., & Jiao, Y. (2015) Transposon mutagenesis paired with deep sequencing of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance. J. Bacteriol. 197, 3160-72.

Kevin S. Myers, Dan M. Park, Nicole A. Beauchene, Patricia J. Kiley, Defining bacterial regulons using ChIP-seq, Methods, Volume 86, 15 September 2015, Pages 80-88, ISSN 1046-2023, http://dx.doi.org/10.1016/j.ymeth.2015.05.022.

Park, D. M.; Jiao, Y., Modulation of medium pH by Caulobacter crescentus facilitates recovery from uranium-induced growth arrest. Appl Environ Microbiol 2014, 80, (18), 5680-8.

Park DM, Kiley PJ. 2014. The influence of repressor DNA binding site architecture on transcriptional control. mBio 5(5):e01684-14. doi:10.1128/mBio.01684-14.

Park DM, Akhtar MS, Ansari AZ, Landick R, Kiley PJ (2013) The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally. PLoS Genet 9(10): e1003839. doi:10.1371/journal.pgen.1003839.

Chung D, Park D, Myers K, Grass J, Kiley P, Landick R, et al. (2013) dPeak: High Resolution Identification of Transcription Factor Binding Sites from PET and SET ChIP-Seq Data. PLoS Comput Biol 9(10): e1003246. doi:10.1371/journal.pcbi.1003246.