MimiYung

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue, L-452
Livermore, CA 94550
email: yung6@llnl.gov
phone: 925 422 7750

         

Education

Ph.D. in Biological Chemistry, Massachusetts Institute of Technology, 2012.
B.S. in Biochemistry, Tufts University, 2006.

Research

My research interests span the fields of synthetic biology, biochemistry, and environmental microbiology. Current projects include: engineering bacterial nano- and micro-compartment systems for synthetic biology applications, developing biocontainment strategies for genetically engineered microorganisms, and developing biosynthetic pathways toward DOE relevant bioproducts and materials.

Recent publications

  1. VanArsdale, E., Navid, A., Chu, M. J., Halvorsen, T. M., Payne, G. F., Jiao, Y., Bentley, W. E., & Yung, M. C. (2023) Electrogenetic signaling and information propagation for controlling microbial consortia via programmed lysis. Biotechnol. Bioeng. 120, 1366-1381. https://doi.org/10.1002/bit.28337.

  2. Halvorsen, T. M., Ricci, D. P., Park, D. M., Jiao, Y., & Yung, M. C. (2022) Comparison of kill switch toxins in plant-beneficial Pseudomonas fluorescens reveals drivers of lethality, stability, and escape. ACS Syn. Biol. 11, 3785-3796. https://doi.org/10.1021/acssynbio.2c00386.

  3. Guzman, M.S., Iyer, J., Kim, P. , Kopp, D., Dong, Z., Foroughi, P., Yung, M. C., Riman, R. E., & Jiao, Y. (2022) Microbial carbonation of monocalcium silicate. ACS Omega 7, 12524–12535. https://doi.org/10.1021/acsomega.1c05264.

  4. Lee, T-H., Carpenter, T. S., D'haeseleer, P., Savage, D. F., & Yung, M. C. (2019) Encapsulin carrier proteins for enhanced expression of antimicrobial peptides. Biotechnol. Bioeng. 117, 603-613. https://doi.org/10.1002/bit.27222.

  5. Yung, M. C.,* Bourguet, F. A., Carpenter, T. S., & Coleman, M. A. (2017) Re-directing bacterial microcompartment systems to enhance recombinant expression of lysis protein E from bacteriophage ϕX174 in Escherichia coli. Microb. Cell Fact. 16, 71. https://doi.org/10.1186/s12934-017-0685-x (*denotes first and corresponding author)

  6. Overton, K. W., Park, D. M., Yung, M. C., Dohnalkova, A. C., Smit, J., & Jiao, Y. (2016) Two outer membrane proteins contribute to Caulobacter crescentus cellular fitness by preventing intracellular S-layer protein accumulation. Appl. Environ. Microbiol. 82, 6961–6972. https://doi.org/10.1128/AEM.02479-16.

  7. Park, D. M., Reed, D. W., Yung, M. C., Eslamimanesh, A., Lencka, M. M., Anderko, A., Fujita, Y., Riman, R. E., Navrotsky, A., & Jiao, Y. (2016) Bioadsorption of rare earth elements through cell surface display of lanthanide binding tags. Environ. Sci. Technol. 50, 2735–2742. https://doi.org/10.1021/acs.est.5b06129.

  8. Yung, M. C., Park, D. M., Overton, K. W., Blow, M. J., Hoover, C. A., Smit, J., Murray, S. R., Ricci, D. P., Christen, B., Bowman, G. R., & Jiao, Y. (2015) Transposon mutagenesis paired with deep sequencing of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance. J. Bacteriol. 197, 3160-72. https://doi.org/10.1128/JB.00382-15.

  9. Yung, M. C. & Jiao, Y. (2014) Biomineralization of uranium by PhoY phosphatase activity aids cell survival in Caulobacter crescentus. Appl. Environ. Microbiol. 80, 4795-804. https://doi.org/10.1128/AEM.01050-14.

  10. Yung, M. C., Ma, J., Salemi, M., Phinney, B. S., Bowman, G. R., & Jiao, Y. (2014) Shotgun proteomic analysis unveils survival and detoxification strategies by Caulobacter crescentus during exposure to uranium, chromium, and cadmium. J. Proteome Res. 13, 1833-1847. https://doi.org/10.1021/pr400880s.

  11. Cho, M., Brigham, C. J., Sinskey, A. J. & Stubbe, J. (2012) Purification of a polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: Implications in the initiation and elongation of polymer formation in vivo. Biochemistry 51, 2276-2288. https://doi.org/10.1021/bi2013596.

  12. Beeby, M., Cho, M., Stubbe, J. & Jensen, G. J. (2012) Growth and localization of polyhydroxybutyrate granules in Ralstonia eutropha. J. Bacteriol. 194, 1092-1099. https://journals.asm.org/doi/10.1128/JB.06125-11.

  13. Korendovych, I. V., Cho, M., Makhlynets, O. V., Butler, P. L., Staples, R. J. & Rybak-Akimova, E. V. (2008) Anion and carboxylic acid binding to monotopic and ditopic amidopyridine macrocycles. J. Org. Chem. 73, 4771-4782. https://doi.org/10.1021/jo800128r.

  14. Korendovych, I. V., Cho, M., Butler, P., Staples, R. J., & Rybak-Akimova, E. V. (2006) Anion binding to monotopic and ditopic macrocyclic amides. Org. Lett. 8, 3171-3174. https://doi.org/10.1021/ol060786r.