Wes Overton

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue, L-452
Livermore, CA 94550
email: overton2@llnl.gov
phone: 925 422 0928


Ph.D. in Chemical Engineering, Stanford University (2014)

M.S. in Chemical Engineering, Stanford University (2010)

B.S. in Chemical Engineering, North Carolina State University (2007)


I am interested in developing and using genetic engineering tools and systems biology to understand how environmental stimuli affect cellular processes.


  1. Park DM, Overton KW, Liou MJ, Jiao Y (2017) Identification of a U/Zn/Cu responsive global regulatory two-component system in Caulobacter crescentus. Molecular Microbiology 104(1):46-64.

  2. Overton KW, Park DM, Yung MC, Dohnalkova AC, Smit J, Jiao Y (2016) Two outer membrane proteins contribute to Caulobacter crescentus cellular fitness by preventing intracellular S-layer protein accumulation. Appl Environ Microbiol 82:6961–6972. doi:10.1128/AEM.02479-16.

  3. Yung, MC, Park, DM, Overton, KW, Blow, MJ, Hoover, CA, Smit, J, Murray, SR, Ricci, DP, Christen, B, Bowman, GR, & Jiao, Y (2015) Transposon mutagenesis paired with deep sequencing of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance. J Bacteriol 197:3160-72
  4. Overton KW, Spencer SL, Noderer WL, Meyer T, & Wang CL (2014) Basal p21 controls population heterogeneity in cycling and quiescent cell-cycle states. Proc Natl Acad Sci U S A 111(44):E4386-E4393.
  5. Yang ZJ, Broz DK, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer T, Tapscott SJ, Attardi LD, & Wang CL (2014) p53 Suppresses Muscle Differentiation at the Myogenin Step. Cell Death Diff. doi:10.1038.
  6. Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, & Meyer T (2013) The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 155(2):369-383.
  7. Ferreira JP, Overton KW, & Wang CL (2013) Tuning gene expression with synthetic upstream open reading frames. Proc Natl Acad Sci U S A 110(28):11284-11289.
  8. Lockney DM, Guenther RN, Loo L, Overton W, Antonelli R, Clark J, Hu M, Luft C, Lommel SA, & Franzen S (2011) The Red clover necrotic mosaic virus capsid as a multifunctional cell targeting plant viral nanoparticle. Bioconjug Chem 22(1):67-73.
  9. Ryan JA, Overton KW, Speight ME, Oldenburg CN, Loo L, Robarge W, Franzen S, & Feldheim DL (2007) Cellular uptake of gold nanoparticles passivated with BSA-SV40 large T antigen conjugates. Anal Chem 79(23):9150-9159.